To complete Bruce's answer about PowerBuilder 12.6:
64-Bit Windows Applications - New Features - SAP Library
System Requirements
The design time environment requires:
- Windows SDK for Windows 7 or later
- .NET Framework 4.0 or later
- 64-bit Windows OS to test (development requires only 32-bit)
The runtime environment requires:
- 64-bit Windows OS
- PowerBuilder 12.6 64-bit system files
- 64-bit third-party libraries, such as database drivers and external DLLs
- Greater than 4 GB physical memory to avoid performance issues