Interesting; I've been running PowerBuilder on my laptops ever since licensing started back on what, 2007; I've always based the license on one of the internal network cards (typically the ethernet port), and have never had an issue.
That said, I have had a similar error to what was posted above when I worked from home for a month and connected to my office desktop computer via RDP. Once the 30 day grace period expires, SySam gets its knickers in a twist and prevents you from starting the IDE. Converting to a served license solved that issue.